Bumrungrad International Hospital
Since we all have di erent DNA , our individual health care
needs are also different .
Bumrungrad Genomic Medicine Center
Getting to know genetic testing
Genes make us unique. At the same time, genes can tell us our health risks as certain diseases such as cancer, heart diseases and other genetic disorders can be passed on to us from those in our family.
Understanding such risks can help us prepare for disease prevention appropriately. Currently, medical genetics testing is available. It can decipher an individual’s genetic codes, thus letting us know beforehand the risks of diseases and allowing us to plan early to avoid the causing factors and prevent them from developing.
passed on from parents... risks of getting diseases unknowingly Genes An example that made headlines around the world was the case of Angelina Jolie (American actress).
cardiovascular diseases
cancer
liver cirrhosis due to excess iron/copper
diabetes
hereditary kidney failure
Her mother died of breast cancer at the age of
dementia
56
,
87 % 5 percent.
prompting her to undergo genetic testing for breast cancer genes, which revealed an She decided to have both breasts removed and thus reduced the risk of breast cancer to only
lifetime risk of developing breast cancer.
genetic What is
testing?
In general, medical diagnosis is based on the patient's history and symptoms along with lab tests. Meanwhile, genetic testing checks for abnormal changes through the analysis of cells or tissues collected from blood samples, buccal swabs, or amniotic fluid in pregnant women. Saliva or skin samples are also possible in some cases.
What are the benefits of genetic testing?
• Helps predict future health. Makes it possible to plan for disease prevention appropriately. • Reduces the risk of drug allergy and helps predict drug response, enabling the right choice of medicine and dosage. • Provides a planning guideline for family members when detected with certain diseases and genetic conditions. • Understanding our genes helps us understand both our own and our family members’ health issues.
People to benefit from genomic screening include:
Couples planning to start a family as the testing can achieve the following:
• find out if the prospective parents carry abnormal genes that can pass diseases on to the children • analyze the embryos for abnormal genetic codes before implantation where assisted reproductive technology such as in vitro fertilization is involved • detect abnormalities in the genetic codes that can cause diseases in infants • look for genetic diseases in unborn children
People with a family history of inherited diseases or those seeking to know if they may have inherited diseases • Heart diseases, cancer, diabetes, etc. • Those with diseases wishing to confirm if they are due to genetic abnormalities • Those wishing to know how severe the diseases they have can turn out • Genetic testing helps doctors decide on the most appropriate types and dosage of medicine for individual patients.
genetic How many types of
testing are
there?
Genetic testing for cancer
Genetic testing for cancer is a proactive approach that can help us identify risks of inherited cancer and plan for effective prevention and monitoring disease development. This program analyzes 65 gene variations associated with various cancers including the BRCA1, BRCA2 genes, which are associated with breast and ovarian cancer, and the APC gene, which is associated with colon cancer. This test can identify risks of more than 10 types of inherited cancer, including
breast cancer colon cancer melanoma stomach cancer ovarian cancer
pancreatic cancer prostate cancer
kidney cancer thyroid cancer uterine cancer
Who should get tested?
a male with breast cancer
1
People with their own or family history of the following:
diagnosed with cancer
multiple types of cancer in the same person
family members with types of cancers above
family members with cancer confirmed as of inherited type
before age 50
2
Those healthy people and without family history of cancer but interested in finding out about risks of inherited cancer
For genetic testing packages, click here .
genetic How many types of
testing are
there?
Genetic testing for cardiovascular diseases
Genetic testing for cardiovascular diseases is a proactive approach that can help us identify risks of inherited cardiovascular diseases and plan for effective prevention and monitoring disease development. This program analyzes 83 gene variations proved to be associated with the following heart diseases:
aortic dissection and aneurysm
severe cardiac arrhythmias
cardiomyopathy causing heart failure
thromboembolism
severe hyperlipidemia
Who should get tested?
2
Healthy people with no family history of heart diseases but seeking to find the risks of developing inherited heart diseases
1
Those with a family history or their own history of the following:
• acute heart attack • relatives’ sudden death during exercise • parents developing heart diseases before age 45 • relatives dying of a heart disease with no known cause • aortic aneurysm or dissection
For genetic testing packages, click here .
genetic How many types of
testing are
there?
Pre-pregnancy genetic testing to nd diseases that may be passed on to children
Genetic diseases are passed on from parents to children. Often, parents may not show any symptoms, as they are simply genetic carriers of the diseases. But when the disease-causing genes are passed on, the diseases are then manifested in children. Commonly found are the fragile X syndrome, muscular atrophy, and congenital hearing loss.
Who should get tested?
Those with a family history of genetic diseases
Those planning to donate eggs, sperm or embryos
Couples planning to have children
Those seeking more information regarding risks of having children with genetic disorders
This test analyzes more than 500 gene variations associated with genetic birth defects.
For genetic testing packages, click here .
Whole Genome / Exome Sequencing
This is an in-depth testing that sequences the entire human genome. The purpose is to assess the risks of cancer, cardiovascular diseases, and other related genetic disorders, with the genetic information kept at the hospital. The package includes four reports on test results regarding cancer, cardiovascular diseases, other related diseases, and pharmacogenomics. The results are based on the analysis of 203 gene variations. The test can help patients detect the diseases they may have early and manage the risks of developing cancer, cardiovascular diseases, and other diseases. This will be useful in planning for prevention and monitoring the genetic disease development. In addition, as Bumrungrad Hospital can retain the analyzed genetic data securely in accordance with international standards, patients can order other genetic tests related to the genetic test results retained (at an additional cost).
This program provides four reports on test results.
1.
Report on cancer risks: Analysis of 92 gene variations, covering 18 cancers as follows: 1) Breast cancer 2) Ovarian cancer 3) Uterine cancer 4) Colorectal cancer 5) Skin cancer 6) Stomach cancer 7) Pancreatic cancer 8) Prostate cancer 9) Renal cell cancer 10) Thyroid cancer 11) Sarcoma cancer 12) Leukemia 13) Brain cancer 14) Lung cancer 15) Endocrine gland cancer 16) Neuroendocrine tumors (NETs) 17) Retinal cancer and 18) Other syndromes. Report on risks of cardiovascular diseases: Analysis of 98 gene variations covering six types of cardiovascular diseases as follows: 1) Aortic abnormalities. 2) Arrhythmias 3) Cardiomyopathy 4) Familial hypertension and Familial hyperlipidemia 5) Inherited vascular abnormalities and 6) Thrombosis.
2.
4.
3.
Report on risks of other diseases: Analysis of 14 gene variations covering nine genetic metabolic diseases and other syndromes
Pharmacogenetics report: Analysis of 2 gene variations covering anesthesia hypersensitivity
This program is suitable for the following people.
• Those with a family history of cancer, cardiovascular diseases or other related diseases • Those healthy people without family history of cancer, cardiovascular diseases or other related diseases but seeking to find the risks of developing such diseases
For genetic testing packages, click here .
genetic How many types of
testing are
there?
Pharmacogenetic testing for drug hypersensitivity and drug metabolism
This program analyzes 11 gene variations, testing 2 genes related to drug hypersensitivity, and 9 genes related to drug metabolism, covering more than 140 drug items.
In what way is pharmacogenetic testing helpful?
To check an individual’s drug response
To enable doctors to select effective medicines for patients
To reduce the chance of side effects of medications
To find out the risks of drug allergy
Testing for drug allergy genes can predict the risk of drug allergy rashes due to the following:
Abacavir, an antiviral inhibitor
Allopurinol, a uric acid reducing drug
Carbamazepine, an anti-epileptic drug and nerve pain reliever
Sulfonamide antibiotics/ Sulfa-containing antibiotics
Dapsone, an antibiotic
Who should get tested?
Those on medications or planning to start them
Those with underlying diseases and taking multiple medications such as children and the elderly
Those seeking to know the test results regarding drug response prediction for future drug use planning
For genetic testing packages, click here .
Genetic testing process at Bumrungrad
2
3
4
List of packages available with saliva samples
Package Advanced genetic health screen (Whole Exome sequencing) plus DNA saving Genetic Cancer Screening
Turn around time
2 months
1 month 1 month
Genetic Heart Screening
Preparing for saliva sample collection
Do not eat, drink, smoke, chew gum, or brush teeth for 30 minutes before sample collection.
1
Saliva collection takes approximately 2 - 5 minutes. Collect the required amount of saliva.
2
3
Do not remove the plastic film from the funnel lid that contains the clear liquid.
Open the sample container. Fill out the history form and sign to complete the document.
4
Would you like to know if you are at risk of serious diseases? โรครายจากพันธุกรรม คลิกแบบสอบถามเพื่อประเมินความเสี่ยง Genomics Risk Assessment เช็คกอน รูทัน เพื่อปองกันการเกิดโรค
Package Genetic TH
Package Genetic EN
สอบถามรายละเอียดเพิ่มเติม ศูนยเวชศาสตรจีโนม บำรุงราษฎร โทร. 02 011 4890, 02 011 4891 (ระหวางเวลา 8.00-18.00 น.)
How to collect saliva samples
คําแนะนําการใชชุดเก็บตัวอยางนํ้าลาย
How to provide a saliva sample
How to collect buccal swab samples
คําแนะนําการใชชุดเก็บตัวอยางเซลลกระพุงแกม
DIY SWAB INSTRUCTION
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